References to AdaptDx in Research

Sevilla MB, McGwin  G, Lad EM, et al. Relating retinal morphology and function in aging and early to intermediate age-related macular degeneration subjects. American Journal of Ophthalmology. 2016;(165):65–77.

Owsley C, McGwin G. Vision-targeted health related quality of life in older adults: patient-reported visibility problems in low luminance activities are more likely to decline than daytime activities. BMC Ophthalmology. 2016;(16):92.

Owsley C, Clark ME, Huisingh CE, Curcio CA, McGwin G. Visual Function in Older Eyes in Normal Macular Health: Association with Incident Early Age-Related Macular Degeneration 3 Years Later. Investigative Ophthalmology & Visual Science. 2016;57(4):1782–1789.

Owsley C, Huisingh C, Clark ME, Jackson GR, McGwin G. Comparison of Visual Function in Older Eyes in the Earliest Stages of Age-related Macular Degeneration to Those in Normal Macular Health. Current Eye Research. 2016;41(2):266–272.

Owsley C, McGwin G, Clark ME, Jackson GR, et al. Delayed Rod-Mediated Dark Adaptation Is a Functional Biomarker for Incident Early Age-Related Macular Degeneration. Ophthalmology. 2016;123(2):344–351.

Owsley C, Huisingh C, Jackson, GR, et al. Associations between abnormal rod-mediated Dark Adaptation and health and functioning in older adults with normal macular health. Investigative Ophthalmology & Visual Science. 2014;55(8):4776–4789.

Neely D, Zarubina AV, Clark ME, et al. Association between visual function and subretinal drusenoid deposits in normal and early age-related macular degeneration eyes. Retina. 2017;37(7):1329–1336.

Neely D, Bray KJ, Huisingh CE, Clark ME, McGwin G, Owsley C. Prevalence of Undiagnosed Age-Related Macular Degeneration in Primary Eye Care. JAMA Ophthalmology. 2017;135(6):570–575.

Richer S, Ulanski-II L, Bhandari A, Popenko N. Longevinex ® Improves Human Atrophic Aged-related Macular Degeneration (AMD) Photoreceptor / Retinal Pigment Epithelium Mediated Dark Adaptation. British Journal of Medicine and Medical Research. 2017;21(10):1–19.

Scott IU, Jackson GR, Quillen DA, Klein R, Liao J, Gardner TW. Effect of doxycycline vs. placebo on retinal function and diabetic retinopathy progression in mild to moderate nonproliferative diabetic retinopathy: a randomized proof-of-concept clinical trial. JAMA Ophthalmology. 2014;132(9):1137–1142.

Scott IU, Jackson GR, Quillen DA, et al. Effect of Doxycycline vs Placebo on Retinal Function and Diabetic Retinopathy Progression in Patients With Severe Nonproliferative or Non–High-Risk Proliferative Diabetic Retinopathy: A Randomized Clinical Trial. JAMA Ophthalmology. 2014;132(5):535.

Owsley C, Clark ME, McGwin G. Natural History of Rod-Mediated Dark Adaptation over 2 Years in Intermediate Age-Related Macular Degeneration. Translational Vision Science & Technology. 2017;6(3):15.

Stem MS, Dunbar GE, Jackson GR, Farsiu S, Pop-Busui R, Gardner TW. Glucose variability and inner retinal sensory neuropathy in persons with type 1 diabetes mellitus. Eye. 2016;(30):825-832.

Thompson AC, Luhmann UFO, Stinnett SS, et al. Association of Low Luminance Questionnaire with Objective Functional Measures in Early and Intermediate Age-Related Macular Degeneration. Investigative Ophthalmology & Visual Science. 2018;59(1):289.

VanderBeek BL. Additional Considerations in the Utility of Dark Adaptometry for the Diagnosis of Age-Related Macular Degeneration. Investigative Ophthalmology & Visual Science. 2014;55(5):3148–3148.

Yazdanie M, Alvarez J, Agrón E, et al. Decreased Visual Function Scores on a Low Luminance Questionnaire Is Associated with Impaired Dark Adaptation. Ophthalmology. 2017;124(9):1332–1339.

Zarubina AV, Huisingh CE, Clark ME, et al. Rod-Mediated Dark Adaptation and Macular Pigment Optical Density in Older Adults with Normal Maculas. Current Eye Research. 2018;43(7):913–920.

Kayser, S., Vargas, P., Mendelsohn, D., Han, J., Bi, H., Benavente, A., & Bittner, A. K. (2017). Reduced Central Retinal Artery Blood Flow Is Related to Impaired Central Visual Function in Retinitis Pigmentosa Patients. Current Eye Research, 42(11), 1503–1510.

Chen, K. G., Alvarez, J. A., Yazdanie, M., Papudesu, C., Wong, W. T., Wiley, H. E., … Cukras, C. A. (2018). Longitudinal Study of Dark Adaptation as a Functional Outcome Measure for Age-Related Macular Degeneration. Ophthalmology.

Cocce, K. J., Stinnett, S. S., Luhmann, U. F. O., Vajzovic, L., Horne, A., Schuman, S. G., … Lad, E. M. (2018). Visual function metrics in early and intermediate dry age-related macular degeneration for use as clinical trial endpoints. American Journal of Ophthalmology.

Mullins, R. F., McGwin, G., Searcey, K., Clark, M. E., Kennedy, E. L., Curcio, C. A., … Owsley, C. (2018). The ARMS2 A69S Polymorphism Is Associated with Delayed Rod-Mediated Dark Adaptation in Eyes at Risk for Incident Age-Related Macular Degeneration. Ophthalmology.

Jackson GR, Scott IU, Kim IK, et al. Author Response: Additional Considerations in the Utility of Dark Adaptometry for the Diagnosis of Age-Related Macular Degeneration. Investigative Ophthalmology & Visual Science. 2014;55(5):3149.

Binns AM, Taylor DJ, Edwards LA, Crabb DP. Determining Optimal Test Parameters for Assessing Dark Adaptation™ in People With Intermediate Age-Related Macular Degeneration. Investigative Ophthalmology & Visual Science 2018; 59: 114-121.

Bittner AK, Seger K, Salveson R, et al. Randomized controlled trial of electro-stimulation therapies to modulate retinal blood flow and visual function in retinitis pigmentosa. Acta Ophthalmologica. 2018;96(3):366–376.

Boynton GE, Stem MS, Kwark L, Jackson GR, Farsiu S, Gardner TW. Multimodal Characterization of Proliferative Diabetic Retinopathy Reveals Alterations in Outer Retinal Function and Structure. Ophthalmology. 2015;122(5):957–967.

Clark ME, McGwin G, Neely D, et al. Association between retinal thickness measured by spectral-domain optical coherence tomography (OCT) and rod-mediated Dark Adaptation in non-exudative age-related maculopathy. Br J Ophthalmol. 2011;(95):1427–32.

Flamendorf J, Agrón E, Wong WT, et al. Impairments in Dark Adaptation Are Associated with Age-Related Macular Degeneration Severity and Reticular Pseudodrusen. Ophthalmology. 2015;122(10):2053–2062.

Holfort SK, Jackson GR, Larsen M. Dark Adaptation during transient hyperglycemia in type 2 diabetes. Exp Eye Res. 2010;(91):710–4.

Holfort SK, Norgaard K, Jackson GR, et al. Retinal function in relation to improved glycaemic control in type 1 diabetes. Diabetologia. 2011;(54):1853–61.

Jackson GR, Clark ME, Scott IU, Walter LE, Quillen DA, Brigell MG. Twelve-month natural history of Dark Adaptation in patients with AMD. Optometry and Vision Science: Official Publication of the American Academy of Optometry. 2014;91(8):925–931.

Jackson GR, Edwards JG. A short-duration Dark Adaptation protocol for assessment of age-related maculopathy. Journal of Ocular Biology, Diseases, and Informatics. 2008;1(1):7–11.

Bavinger JC, Dunbar GE, Stem MS, et al.  The Effects of Diabetic Retinopathy and Pan-Retinal Photocoagulation on Photoreceptor Cell Function as Assessed by Dark Adaptometry. Investigative Ophthalmology & Visual Science. 2018;57(1):208–217.

Jackson GR, Scott IU, Kim IK, Quillen DA, Iannaccone A, Edwards JG. Diagnostic Sensitivity and Specificity of Dark Adaptometry for detection of Age-Related Macular Degeneration. Investigative Ophthalmology & Visual Science. 2014;(55):1427–1431.

Jackson GR, Scott IU, Quillen DA, Walter LE, Gardner TW. Inner retinal visual dysfunction is a sensitive marker of non-proliferative diabetic retinopathy. Br J Ophthalmol. 2011;(96):699–703.

Klefte ON, Holfort SK, Larsen M. Baseline haemoglobin A1c influences retinal function after long-term insulin pump therapy. Graefe’s Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. 2016;254(3):467–473.

Klefter ON, Hommel E, Munch IC, Nørgaard K, Madsbad S, Larsen M. Retinal characteristics during 1 year of insulin pump therapy in type 1 diabetes: a prospective, controlled, observational study. Acta Ophthalmologica. 2016;94(6):540–547.

Laíns I, Miller JB, Mukai R, et al. Heath Conditions Linked to Age-Related Macular Degeneration Associated with Dark Adaptation. Retina. 2018;38(6):1145–1155.

Laíns I, Park DH, Mukai R, et al. Peripheral Changes Associated With Delayed Dark Adaptation in Age-Related Macular Degeneration. American Journal of Ophthalmology. 2018;(190):113–124.

Laíns I, Miller JB, Park DH, et al. Structural Changes Associated with Delayed Dark Adaptation in Age-Related Macular Degeneration. Ophthalmology. 2017;124(9):1340–1352.

Messerlin A, Greth A, Bourcier T et al. Dark Adaptation changes in highly myopic patients. European Journal of Ophthalmology. July 2018.

Munch IC, Altuntas C, Li XQ, Jackson GR, Klefter ON, Larsen M. Dark Adaptation in relation to choroidal thickness in healthy young subjects: a cross-sectional, observational study. BMC Ophthalmology. 2016;(16):105.