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Dark Adaptation Research

Dark Adaptation Study for the Detection of AMD

This pivotal study of dark adaptation was conducted at Harvard, Johns Hopkins, and Penn State universities. It found the AdaptDx® Rapid Test for dark adaptation is a highly accurate measure of dark adaptation speed, which gives a clear, objective measurement of retinal function with 90% sensitivity and 90% specificity for the presence of AMD.


Peer-Reviewed Publications

Confidence in the sensitivity and specificity of AdaptDx has led to over 40 peer-reviewed publications.

Research & Education

Leading institutions have used AdaptDx technology for research and education, including:

University of Alabama in Birmingham
Harvard University
University of Bonn
Moorfields Eye Hospital
National Eye Institute
Penn State Hershey
University of Copenhagen
Nova Southwestern University
Ohio State University College of Optometry
Keck School of Medicine of University of Southern California
Massachusetts College of Pharmacy and Health Sciences
Duke Eye Center
University of Michigan
Institut Macula Retina
Queen's University of Belfast
Taipei Medical Univesity Hospital
University of Ulster
WillsEye Hospital
Lahey Hospital & Medical Center
University of Iowa
University of Wisconsin
City University
Stumptown Mennonite Church
Rosenberg School of Optometry
Massachusetts College of Pharmacy
Retina Foundation of the Southwest
New York Eye & Ear
University of Wisconsin
Moran Eye Center
Marshall Ketchum Uni
Schepens Eye Research
University Eye Hospital Ulm
Porto Medical
Callahan Eye Hospital
Scheie Eye Institute
Atlanta VA Medical Center
Glouchestershire Retinal Research
Lin BioScience, Inc
Massachusetts Eye-Ear-Infirmary
Wooster Eye Center
Centre for Clinical Trials
Centre Hospitalier
STZ Biomed Eyetrial Center
Klinik Frreiburg
University Eye Hospital Munich
G.B. Bietti Eye Foundation
Luigi Sacco
Unviersity Vita Salute logo
Capt James Lovell logo

Major Study Participation

AdaptDx was chosen as a clinical endpoint in two current multi-year international studies of macular degeneration—MACUSTAR and ARIS.


The AdaptDx was selected as a key testing device in the MACUSTAR project, a five-year study aimed at reducing the disease burden of AMD worldwide. Currently funded with more than 16 million euros from the European Union and leading European pharmaceutical companies, the investigation expects to enroll 750 patients in seven countries across Europe.

The research project will be conducted at 20 clinical study centers in Europe, including:

  • University Eye Clinic Bonn and the GRADE Reading Center Bonn
  • Moorfields Eye Hospital
  • University College
  • City University
  • Fondation voir et entendre Paris
  • Coimbra Association for Innovation and Biomedical Research on Light and Image (AIBILI)
  • Radound University Medical Center
  • University of Sheffield
  • European Clinical Research Infrastructures Network (ECRIN) Paris

AMD Ryan Initiative Study (ARIS):
Led by the National Eye Institute

This clinical study will follow 500 people over five years to learn more about the natural history of early age-related macular degeneration (AMD). Researchers will use the latest technologies, including AdaptDx, to measure function and visualize structures within the eye. The hope is to identify biomarkers of disease progression well before it advances to late-stage disease and causes vision loss.

All ARIS participants will undergo routine spectral domain optical coherence tomography (SD-OCT); and visual function will be measured by dark-adapted fundus perimetry and dark adaption. Dark adaptation studies are relevant because AMD tends to first damage rod photoreceptors (the retinal cells that allow for vision under dim conditions) earlier than it does cone photoreceptors, which enable daylight vision. Researchers at each of the 20 ARIS study sites will track drusen volume changes as well as other findings on SD-OCT to see if they correspond to functional changes in visual acuity and dark adaptation.

When I look at the future of managing macular degeneration, I see the AdaptDx as the essential tool in AMD management just as now I see the OCT as the essential tool in managing glaucoma in its earliest stages. By finding a disease early, and intervening appropriately we have the best chance of altering the course.

Thomas Henderson Thomas Henderson, MD View all testimonials


Eye care professionals discuss how the AdaptDx Pro® benefits their practices.



MacuLogix clinical advisers demonstrate how AdaptDx Pro has the potential to improve patient outcomes.



Evidence-based guides include the latest information on AMD classification, diagnosis, staging, and treatment.

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AdaptDx Pro Can Help Detect AMD

The AdaptDx Pro testing tool from MacuLogix offers you the chance to diagnose AMD in patients before vision loss occurs.

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